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Faculty of Biology and Biotechnology :
Chair of General Zoology and Neurobiology AG Behavioral Neuroscience
In order to fill a fixed-term position in part-time (25.8895 hours/week = (65%)) at the earliest possible date, we are looking for a
PhD position (m/f/x) Behavioral Neuroscience
The research group Behavioral Neuroscience investigates the multifaceted functions of the cerebellum beyond its classical role in motor control, with a particular focus on neurological and psychiatric disorders. By developing and studying transgenic mouse models of episodic and spinocerebellar ataxias, the team explores how specific cell types, signaling pathways, and molecular mechanisms contribute to disease progression. These studies aim to uncover targets for innovative therapeutic interventions. In addition, the group is interested in the cerebellum’s involvement in emotional and cognitive processes, especially in the regulation of fear and anxiety. Using a combination of genetic, optogenetic, and pharmacological approaches, they dissect the contributions of distinct neuronal populations and brain circuits, thereby providing new insights into how the cerebellum shapes and contributes to both behavior and pathology. The proposed project aims to investigate specific GPCRs expressed in the cerebellum whose endogenous ligands and physiological functions remain unknown (so-called orphan GPRs). Many orphan GPRs are associated with neurodegenerative and neurological conditions in both human and mouse. To help understand the physiological role of certain orphan GPRs, as well as identify their ligands and signaling pathways, a range of in vitro experiments will be conducted initially. As the project advances, individual orphan GPCRs will be studied in different mouse models to elucidate their contribution to both normal cerebellar function and neurodegenerative disease.
As a research assistant (m/f/x), you will independently and reliably prepare and carry out experiments, analyse the results and …
Scope: part-time
Duration: fixed-term, 3 years
Start: at the earliest possible date
Apply by: 2026-02-02
Your tasks:
- Molecular biology: Cloning of various plasmids and sensors using standard molecular biology techniques (PCR, restriction digest, ligation, etc.)
- Cell culture: Culturing, passaging, transfection, and generation of stable GPCR-specific cell lines for in vitro studies; performing assays to identify GPCR signalling pathways
- Biochemical assays: Co-immunoprecipitation, Western blotting, highperformance liquid chromatography coupled with mass spectrometry.
- Fluorescence microscopy: and analysis of fluorescent images; performing calcium imaging
- Animal experiments: Conducting and analyzing behavioral experiments in mice; organ extraction followed by histological analyses (IHC, qPCR, Western blot)
- Electrophysiology: In vivo recordings and analysis of Purkinje cell activity
- Supervision: Support in supervising Bachelor’s and Master’s theses, as well as participation in specialized and advanced training modules
Your profile:
We are looking for a candidate (m/f/x) with an excellent Master’s degree in Biology with a
focus on Neurobiology/Neuroscience or a comparable field. Ideally, the candidate
should have the following qualifications:
- Excellent English language skills
- Experience in planning and conducting molecular biology experiments
- Experience in cell culture techniques
- Experience in animal experimentation (FELASA B certification required; can be obtained before employment starts)
- Strong skills in project planning and collaborative research
We are looking for an open-minded, extroverted, and scientifically enthusiastic
individual who stands out through teamwork, independence, accuracy, and
excellent academic achievements. Willingness to learn new methods and to give
presentations in English are expected.
We offer:
- Challenging and varied tasks with a high degree of personal responsibility
- Employment at one of Germany’s largest universities within the University Alliance Ruhr
- Comprehensive onboarding and training
- Interdisciplinary collaboration within an international, committed, and openminded team
- Workshops, conferences, symposia, and journal clubs for interdisciplinary exchange
- Support in balancing family and career (childcare placement, holiday programs, mobile childcare facilities)
- Extensive opportunities for professional development and continuing education
- A diverse range of sports activities with around 100 sports and the university’s own fitness studio
Further information:
The position is salaried and based on the collective agreement of the Länder (TV-L). If the personal and collective agreement requirements are met, the employee will receive pay grade E13 TV-L.
Further information can be found at (in German).
The place of work is Ruhr University Bochum.
The load of teaching will be calculated according to § 3 of Lehrverpflichtungsverordnung (state of North Rhine-Westphalia).
RUB sees itself as a university with an international presence. The campus languages are German and English. Competence in at least one of the two languages and the willingness to learn the other are a prerequisite. RUB provides corresponding free courses for employees.
German language courses are offered by the University Language Center (ZFA) in the field of German as a Foreign Language (DaF). https://www.daf.ruhr-uni-bochum.de/sbgk/index.html.en
The Staff Council has the right to participate in all selection interviews. At the request of a candidate (m/f/x), it will ensure its participation in the entire procedure. Please contact wpr@rub.de.
The Ruhr-Universität Bochum is one of Germany’s leading research universities, addressing the whole range of academic disciplines. A highly dynamic setting enables researchers and students to work across the traditional boundaries of academic subjects and faculties. To create knowledge networks within and beyond the university is Ruhr-Universität Bochum’s declared aim.
The Ruhr-Universität Bochum stands for diversity and equal opportunities. For this reason, we favour a working environment composed of heterogeneous teams, and seek to promote the careers of individuals who are underrepresented in our respective professional areas. The Ruhr-Universität Bochum expressly requests job applications from women. In areas in which they are underrepresented they will be given preference in the case of equivalent qualifications with male candidates. Applications from individuals with disabilities are most welcome.
Contact persons for further information:
Dr. Pauline Bohne-Rybarski +49 234 32 24541
Prof. Dr. Melanie D. Mark +49 234 32 27913
Travel costs, accommodation costs and loss of earnings or other application costs for job interviews can unfortunately not be reimbursed.
We look forward to receiving your application via our online application portal by 2026-02-02. Please make sure to mention the reference number ANR 5279.
RUHR-UNIVERSITÄT BOCHUM
44801 Bochum
Universitätsstraße 150
SOCIAL MEDIA