Postdoctoral Researcher (f/m/d): Biomolecular Phase Transitions from Microfluidics to Processes

Application until2026-10-23

Start of workAs soon as possible

Scope of work39 h

Are you an experimentalist fascinated by how proteins and peptides condense, aggregate and crystallize? Join the newly established research group at the , Germany. The position is to be filled as soon as possible and is limited to three years.

About the group
We study how solids and other condensed phases form from fluids, from nucleation and crystal growth to protein aggregation and phase separation. We then turn this understanding into better processes. Our approach combines theory and modeling, droplet microfluidics and process-scale experiments, with a focus on biomolecules such as peptides and proteins.

The project
Proteins, peptides, and other biomolecules undergo a rich variety of phase transitions: they demix into liquid condensates, form amorphous aggregates or amyloid fibrils, or crystallize. These transitions govern the formation of functional and pathological assemblies in living cells. They also determine how biopharmaceuticals can be purified and formulated. Yet quantitative data on their thermodynamics and kinetics remain scarce. Classical bulk experiments are slow and consume prohibitively large amounts of material.

In this project, you will use droplet microfluidics to study biomolecular phase transitions with high throughput and minimal sample consumption. Splitting a sample into thousands of nanoliter droplets makes it possible to resolve stochastic phenomena such as nucleation, to efficiently map phase diagrams and to measure kinetics with excellent statistics. You will complement these measurements with bulk assays at larger scales. Together with the theory and modeling efforts in the group, you will contribute to fundamental advancements in our understanding of biomolecular phase transitions and their role in industrial processes. Within this framework, you will have the freedom to develop your own research questions.
As one of the first members of the group, you will play a key role in setting up the experimental lab, including a liter-scale precipitation platform that complements the microfluidic experiments at the process-scale. You will also have opportunities to mentor PhD students, in particular regarding the development of experimental platforms and methodologies.

Your tasks

Help establish the group's microfluidics and biomolecular lab
Design and carry out microfluidic and bulk experiments on phase separation, aggregation and crystallization of proteins and peptides
Contribute to the development of a liter-scale precipitation platform, bridging the scales from droplets to processes
Quantify thermodynamics and kinetics, such as phase diagrams and nucleation and growth rates, and interpret them together with theory and modeling
Mentor PhD and Master's students
Publish in leading journals, present at international conferences and contribute to grant proposals

Your profile

PhD in chemical or bioengineering, biophysics, physical chemistry, biochemistry, physics or a related discipline
Hands-on experience with microfluidics (e.g. device fabrication, droplet generation) and fluorescence microscopy
Experience in handling and characterizing biomolecules such as proteins or peptides
A quantitative mindset and interest in linking experiments with theory
A strong publication record relative to career stage
Team spirit, good communication skills and very good knowledge of English; basic proficiency in German would be a plus
Experience with liquid–liquid phase separation, protein aggregation or crystallization, image analysis and programming (e.g. Python), or supervising students is a plus.

We offer

The opportunity to develop your own research questions within the group's research program, with mentoring towards an independent career, including support with fellowship and grant applications
The opportunity to help build up the lab of a young group
The infrastructure and resources of a Max Planck Institute
An interdisciplinary, international team and a network with leading universities and industrial partners
Funding for international conferences, plus career development and training programs of the Max Planck Society
A three-year contract and salary according to TVöD (Bund), E13, 100 %
We also welcome candidates interested in applying for postdoctoral fellowships (e.g. MSCA, Humboldt) to join the group.

The is committed to equal opportunities, gender equality and diversity. What matters to us are your qualifications, professional strengths and attitude. We therefore welcome applications from all backgrounds, regardless of gender, cultural or social background, disability, religion, age, lifestyle, ideology, or sexual identity.

One of the Max Planck Society's primary goals is to increase the proportion of women in areas where they are underrepresented. We are therefore particularly interested in applications from qualified women and would like to encourage them to apply.

The Max Planck Society is also committed to employing more severely disabled people. Severely disabled people and those with an equivalent status will be given special consideration if they are equally qualified. We therefore explicitly encourage applications from severely disabled people.

We will be assessing applications on an ongoing basis until the position is filled. Please register via our online application portal below and upload your complete application documents (letter of motivation, CV, certificates, reference letters).

Contact person for further information: