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Institution Faculty of Medicine - Anatomische Anstalt Lehrstuhl 1 Remuneration group TV-L E13 Full-time / Part-time Part-time (65%) Start date 01.04.2026 Application deadline 2026-01-31

brings together leading scientists in medicine (dermatology, pediatrics, internal medicine and surgery), molecular biology, immunology, biomedicine, and systems research to investigate fundamental mechanisms underlying development of diseases related to desmosome disorders.

Within the scope of this SFB/TRR several projects of the Department of Vegetative Anatomy of the LMU in Munich were approved. One of the projects A03 – “Super-resolution force spectroscopy to delineate early pathogenic effects of autoantibodies and cytokines in desmosome dysfunction” will be carried out here and led by Michael Fuchs.

Project no A03

In this project we will investigate the biophysical binding properties of desmosomal cadherins and the precise sequence of signaling events following a pathogenic stimulus, i.e. autoantibodies or cytokines. For this purpose, atomic force microscopy (AFM), single molecule force spectroscopy (SMFS), and stimulated emission depletion (STED) microscopy will be used in combination with biochemical approaches. The main goal is to decipher the precise spatiotemporal sequence of events following a pathologic stimulus as well as the interplay between steric hindrance and altered signaling pathways.

We are looking for you:

Doctoral Fellow / Candidate (PhD) (m/f/x)

in Munich

Your tasks and responsibilities:

• You are supposed to fulfil the research of the A03-project within the SFB/TRR 425
• Communication and coordination of the labwork related to the project A03, which has to be integrated in our ongoing labwork of the department, as well as into the other projects of the SFB/TRR to be carried out in Munich
• Preparation of the obtained data and their appropriate presentation within the SFB/TRR and at conferences

Your qualifications:

• Master’s degree (or equivalent) in biology, biochemistry, molecular medicine, biophysics, bioinformatics, or a related field
• Strong interest in mechanistic and translational biomedical research
• Hands-on experience with laboratory and analytical methods relevant to the specific project (cell-culture, microbiological and biochemical investigations, image analysis and data processing) and analytical thinking. Strong interest in biophysical techniques (AFM, STED). Experience with super-resolution imaging techniques and/or AFM is a plus
• Highly motivated with the ability to work both independently on experimental tasks and collaboratively within an interdisciplinary team
• Proficiency in English, German skills are beneficial but not required

Benefits:

• A fully funded position according to DFG/TV-L guidelines (TV-L E13 65%)
• Close exchange with the researchers working in this multidisciplinary research consortium
• Access to state-of-the-art research facilities at the LMU (Confocal-, STED-, Atomic-Force-Microscopy, Electron Microscopy)
• Structured doctoral training within the Integrated Research Training Group (IRTG) and CRC DEFINE
• A highly collaborative, international research environment
• Close exchange with researchers from Munich, Marburg and Würzburg being part of this CRC
• Your workplace is in the city-center of Munich and easily accessible by public transport

The position is limited in duration in accordance to the funding period for 3 years and 9 months. The application for prolongation of the consortium is planned.

People with disabilities who are equally as qualified as other applicants will receive preferential treatment.

Contact:

Submit your application by 31st Jan 2026 in a pdf-file to:

If further information about the position or the scientific work is needed in advance, please contact:

Dr. Michael Fuchs, Tel

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